伤害感受器
三叉神经节
轴突
医学
伤害
三叉神经
神经科学
钠通道
麻醉
解剖
感觉系统
心理学
受体
内科学
化学
钠
有机化学
作者
Mohammad-Reza Ghovanloo,Philip R Effraim,Jun-Hui Yuan,Betsy R Schulman,Deborah S. Jacobs,Sulayman D. Dib-Hajj,Stephen G. Waxman
标识
DOI:10.1152/jn.00457.2022
摘要
Mechanisms underlying pain after axonal injury remain elusive. A small subgroup of patients experience pain after corneal refractive surgery, providing a human pain model after well-defined injury to axons. Here we analyze a mutation (P610T) in Nav1.7, a threshold sodium channel expressed in nociceptors, found in two siblings with persistent ocular pain after refractive surgery. We show that it impairs channel slow inactivation, thereby triggering inappropriate repetitive activity in trigeminal ganglion axons that signal eye pain.
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