Under the background of rapid development and sustainable development of China's high-speed railways, studying the impact of construction and operation of high-speed railways on regional economic development and its mechanism has both high theoretical attraction and practical significance.This paper selects Xi'an-Chengdu highspeed railway as a more important instance in Western China.High-speed railways are the research objects.The economic development along high-speed railways is studied using the double-difference and least-squares linear regression models.The following conclusions are drawn in this paper.In China's central and western regions, it is necessary to construct a high-speed railway to connect the two regional central cities.Such projects can bring more benefits to underdeveloped areas along high-speed railways."For objective economic growth.At the same time, this study proves the necessity and importance of building high-speed railways in such underdeveloped areas as western China.The results can be extended to other underdeveloped areas in China and even the world.