A study of serum hsCRP level to assess severity in patients with psoriasis ( A study of 50 patients and 50 controls )

Introduction: Psoriasis is a common chronic skin disease, characterized by sharply demarcated, erythematous, scaly plaques. Psoriasis is supposed to be initiated by interplay between genetic, environmental, and immunological factors. Creactive protein (CRP) has special importance for psoriasis due to its relation with cytokines which are responsible for skin inflammation. The present study determine the level of CRP by using highly sensitive method (hs-CRP) with a detection limit 0.25mg/L and its correlation with severity of disease. Material and Methods: 50 Patients diagnosed as having psoriasis and 50 age and sex matched normal healthy control were studied after taking their consent. Psoriasis patients with Psoriasis Area Severity Index (PASI) less than 10 considered as mild Psoriasis and PASI greater than 10 considered as moderate to severe Psoriasis. Blood sample was collected under aseptic precautions in plain vacutainer for hsCRP estimation. hsCRP estimation done by latex turbidimetric method. Results: The present study found significant correlation between hsCRP and PASI ( p 0.0001). Mean value of hsCRP in PASI 10 (mild psoriasis ) is 1.34 mg/L