对映选择合成
酮
化学
催化作用
产量(工程)
对映体
有机化学
水杨酸
对映体过量
材料科学
生物化学
冶金
作者
Yılmaz Turgut,Murat Azizoglu,Aslı Erdogan,Nevin Arslan,Halil Hoşgören
标识
DOI:10.1016/j.tetasy.2013.05.016
摘要
In order to find the most effective catalyst for the enantioselective reduction of a prochiral ketone, a series of novel β-hydroxyamide derivatives of salicylic acid and chiral amino alcohols were synthesized. Different substituted prochiral ketones have been reduced in high yield (up to 99%) and the corresponding secondary alcohols are formed with good enantiomeric excess (up to 86%). The mechanism of this type of catalyst can be explained by considering the reaction mechanism for the CBS catalyst.
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