俱乐部
生物
肺病
疾病
细胞
杂志社
免疫系统
慢性阻塞性肺病
免疫学
计算生物学
生物信息学
医学
病理
遗传学
内科学
解剖
作者
Jessica B Blackburn,Ngan Fung Li,Nathan W. Bartlett,Bradley W. Richmond
出处
期刊:American Journal of Physiology-lung Cellular and Molecular Physiology
[American Physiological Society]
日期:2023-05-01
卷期号:324 (5): L652-L665
被引量:3
标识
DOI:10.1152/ajplung.00192.2022
摘要
Club cells are found in human small airways where they play an important role in immune defense, xenobiotic metabolism, and repair after injury. Over the past few years, data from single-cell RNA sequencing (scRNA-seq) studies has generated new insights into club cell heterogeneity and function. In this review, we integrate findings from scRNA-seq experiments with earlier in vitro, in vivo, and microscopy studies and highlight the many ways club cells contribute to airway homeostasis. We then discuss evidence for loss of club cells or club cell products in the airways of patients with chronic obstructive pulmonary disease (COPD) and discuss potential mechanisms through which this might occur.
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