PI3K/AKT/mTOR通路
蛋白激酶B
前列腺癌
癌症研究
医学
乳腺癌
癌症
信号转导
前列腺
肿瘤科
生物信息学
内科学
生物
细胞生物学
作者
Mateusz Wylaź,A. Kaczmarska,Dawid Pajor,Matthew Hryniewicki,Dorota Gil,Joanna Dulińska-Litewka
标识
DOI:10.1016/j.biopha.2023.115676
摘要
Breast cancer (BC) and prostate cancer (PC) are at the top of the list when it comes to the most common types of cancers worldwide. The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway is important, in that it strongly influences the development and progression of these tumors. Previous studies have emphasized the key role of inhibitors of the PIK3/AKT/mTOR signaling pathway in the treatment of BC and PC, and it remains to be a crucial method of treatment. In this review, the inhibitors of these signaling pathways are compared, as well as their effectiveness in therapy and potential as therapeutic agents. The use of these inhibitors as polytherapy is evaluated, especially with the use of hormonal therapy, which has shown promising results.
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