Abstract Lupus occurring in children causes similar types of clinical features to that found in adults but there are special problems relating to growth and the need to overcome particular problems of poor adherence. Lupus occurring in those over 55 is associated with an increased risk of damage. The best chance of a good outcome for pregnancy in lupus patients is to ensure that they have been in remission for some time before conceiving. Co-managing a pregnancy with a rheumatologist and obstetrician is strongly advised. Although lupus primarily targets women between the ages of 15 and 45 years, young children and older adults may also develop lupus. Some medications can cause a lupus-like illness. These special situations warrant further discussion.