Impact of telitacicept on gonadal function in adult female patients with systemic lupus erythematosus: a prospective cohort study

Background/Aim: Telitacicept has shown promise in disease control of systemic lupus erythematosus (SLE). This study aimed to evaluate the impact of telitacicept on gonadal function in adult female patients with SLE. Methods: In this prospective cohort study, adult female SLE patients aged 18 to 45 years were included and divided into telitacicept and non-telitacicept group. Hormonal levels of estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), and anti-Müllerian hormone (AMH) were measured at baseline, month 1, 3, and 6 post-treatment. Generalized estimating equations adjusting for baseline confounders was used. Results: >0.05). SLE Disease Activity Index scores were significantly lower with telitacicept compared to non-telitacicept treatment at month 1, 3 and 6 post-treatment (all P<0.05). The incidence of adverse events was similar between the two groups. Conclusion: Telitacicept demonstrates significant benefits in improving gonadal function and controlling disease activity in female SLE patients.