Polysaccharide micelle hydrogel delivery Ginkgolide B for wound healing

Wound healing is a complex process encompassing the inflammatory, proliferative, and remodeling phases; however, infection, oxidative stress, and prolonged inflammation can impede recovery, leading to chronic wounds. Ginkgolide B (GB), a bioactive diterpene with anti–inflammatory and antioxidant activities, shows promise for promoting wound repair; however, its clinical use is hampered by poor solubility and low bioavailability. To overcome these limitations, we developed natural polysaccharide polymeric micelles (GBM) to enhance GB delivery and a dual–crosslinked hydrogel dressing composed of methacrylated silk fibroin and oxidized laminaria polysaccharide (Laminaria-Silk fibroin hydrogel, LSH). GBM improves GB solubility and bioavailability, whereas the LSH hydrogel—formed via Schiff–base chemistry and UV–induced photocrosslinking—provides a moist, bioactive wound microenvironment. This integrated system leverages the self–assembling properties of polysaccharide micelles for efficient drug delivery and the dynamic reversibility of the hydrogel network for sustained release, resulting in a biocompatible and effective strategy for managing chronic wounds. Our findings highlight the potential of natural compound–based hydrogels to enhance wound healing through synergistic drug delivery and tissue regeneration.