Electrochemical 1,5-Aryl Migration for Stereo- and Regioselective Synthesis of Tetrasubstituted Alkenes

An electrochemical 1,5-aryl migration protocol for the stereo- and regioselective synthesis of Se-containing tetrasubstituted α,β-unsaturated amides has been developed. This approach leverages readily available N-benzylpropiolamides and diselenides as starting materials and proceeds without the need for oxidants or metal reagents. The simplicity of the protocol is further enhanced by its execution in a straightforward undivided electrolytic cell at room temperature, providing an efficient and innovative route for the synthesis of challenging tetrasubstituted alkenes.