芳基
化学
羰基化
催化作用
镍
组合化学
有机化学
药物化学
一氧化碳
烷基
作者
Chen Chen,Luyao Ding,Xiao-Xu Zhang,G Chen,Yanping Zhu,Chunjie Ni,Bolin Zhu
出处
期刊:Organic Letters
[American Chemical Society]
日期:2025-05-01
卷期号:27 (19): 4915-4920
被引量:5
标识
DOI:10.1021/acs.orglett.5c01203
摘要
A nickel-catalyzed site-selective reductive carbonylation of arenes via aryl thianthrenium salts is described. Using Mo(CO)6 as a convenient solid CO source and reductant and employing nitroarenes and sulfonyl chlorides as readily available nitrogen and sulfur sources, a range of aryl amides and aryl thioesters were successfully synthesized in moderate to good yields. The utility of this transformation is demonstrated through the synthesis of antimicrobial agents and the late-stage functionalization of biorelevant molecules.
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