卵巢癌
生物
浆液性液体
卵巢癌
肿瘤科
浆液性卵巢癌
浆液性癌
内科学
免疫系统
肿瘤微环境
脂肪酸代谢
生物信息学
癌症研究
脂肪酸
癌症
医学
免疫学
生物化学
作者
Lele Ye,Zhinong Jiang,Mengxia Zheng,Kan Pan,Jingru Lian,Ju Bai,Xuefei Liu,Sha Tang,Gangqiang Guo,Songfa Zhang,Xin Hong,Weiguo Lü
出处
期刊:Epigenomics
[Future Medicine]
日期:2024-03-01
卷期号:16 (5): 309-329
被引量:1
标识
DOI:10.2217/epi-2023-0388
摘要
Background: To explore the role of fatty acid metabolism (FAM)-related lncRNAs in the prognosis and antitumor immunity of serous ovarian cancer (SOC). Materials & methods: A SOC FAM-related lncRNA risk model was developed and evaluated by a series of analyses. Additional immune-related analyses were performed to further assess the associations between immune state, tumor microenvironment and the prognostic risk model. Results: Five lncRNAs associated with the FAM genes were found and used to create a predictive risk model. The patients with a low-risk profile exhibited favorable prognostic outcomes. Conclusion: The established prognostic risk model exhibits better predictive capabilities for the prognosis of patients with SOC and offers novel potential therapy targets for SOC.
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