核酸
免疫疗法
免疫系统
疾病
嵌合抗原受体
细胞疗法
生物
计算生物学
细胞生物学
癌症研究
免疫学
医学
干细胞
生物化学
病理
作者
Hannia V. Balcorta,Veronica Guerrero,Deepali Bisht,Wilson Poon
出处
期刊:ACS applied bio materials
[American Chemical Society]
日期:2024-01-30
标识
DOI:10.1021/acsabm.3c00886
摘要
In medicine, it is desirable for clinicians to be able to restore function and imbue novel function into selected cells for therapy and disease prevention. Cells damaged by disease, injury, or aging could be programmed to restore normal or lost functions, such as retinal cells in inherited blindness and neuronal cells in Alzheimer's disease. Cells could also be genetically programmed with novel functions such as immune cells expressing synthetic chimeric antigen receptors for immunotherapy. Furthermore, knockdown or modification of risk factor proteins can mitigate disease development. Currently, nucleic acids are emerging as a versatile and potent therapeutic modality for achieving this cellular programming. In this review, we highlight the latest developments in nanobiomaterials-based nucleic acid therapeutics for cellular programming from a biomaterial design and delivery perspective and how to overcome barriers to their clinical translation to benefit patients.
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