Efficacy of intracytoplasmic sperm injection in women with non-male factor infertility: A systematic review and meta-analysis

Review question / Objective: This meta-analysis aims to evaluate whether intracytoplasmic sperm injection (ICSI) improved reproductive outcomes for non-male factor infertility versus in vitro fertilization (IVF). Condition being studied: The use of ICSI has increased dramatically in recent years and is being applied for indications other than male factor infertility. However, despite its increased use, there is no clear evidence of the benefit of using ICSI over conventional IVF for non-male factor infertility. Eligibility criteria: Studies will be excluded if one of the following conditions is met: (1) unqualified male perm count and motility; (2) rescued ICSI; (3) non-RCTs of study design; (4) a significant amount of research data is missing or not available.