DNA修复
基底切除修复术
基因组不稳定性
核苷酸切除修复
DNA错配修复
同源重组
DNA损伤
生物
癌症研究
DNA
细胞生物学
遗传学
出处
期刊:Pakistan Journal of Biological Sciences
[Science Alert]
日期:2023-01-15
卷期号:26 (1): 15-22
被引量:2
标识
DOI:10.3923/pjbs.2023.15.22
摘要
The DNA is constantly under attack from endogenous and exogenous damaging agents. The damaged DNA must be repaired quickly to avoid genomic instability and to prevent the occurrence of a malignant transformation. Once a lesion is detected, the DNA repair mechanism initiates and replaces the structurally altered base or any other abnormality. The cell repair mechanisms include direct reversal, excision repair (base excision repair [BER] and nucleotide excision repair [NER]), mismatch repair (MMR), homologous recombination repair (HR) and non-homologous end joining (NHEJ). Unrepaired DNA could lead to mutation, cell death or cancer. This review will discuss how the defects in DNA repair play a vital role in cancer initiation, development and progression.
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