p-Methoxybenzyl as a New N3-Imide Protecting Group of 5-Fluorouridine and Its Application to the Synthesis of 5′-O-Acryloyl-5-fluorouridine

Abstract 5′-O-Acryloyl-5-fluorouridine was prepared by use of p-methoxybenzyl(PMB) group as a new N3-imide protecting group of 5-fluorouridine. A chemoselective method for protection has been developed by use of ethyldiisopropylamine as a base and deprotection was effected by AlCl3-anisole system.