Cellular transduction of periodic and stochastic energy signals by electroconformational coupling

Introduction The transport of life-sustaining materials across the cell membrane consumes large fractions of the total energy expenditures of cells. As such, membrane transport is tightly regulated and controlled. Membrane proteins are mostly responsible for the transport of molecules and ions in and out of the cell. There are many classes of membrane transporters. A simple classification lists three types: channels , carriers and pumps . Channels and carriers are passive downhill transporters, whereas pumps are active uphill transporters. However, a channel may also be able to fulfill the role of an uphill transporter by coupling a downhill transport reaction to an uphill transport reaction: the transporter, however, will still be a downhill transporter overall. Beside proteins, a small number of transporters come from heterocyclic organic compounds. These small molecules can serve as ion channels or ion carriers, but only a protein with enzymatic activity can function as a pump. All transporters are embedded in lipid bilayers and, for a pump to function, some degrees of freedom must be hindered or restricted. As I shall discuss later, this feature of a pump is crucial for capturing energy from a periodically oscillating or randomly fluctuating force field (Tsong and Astumian, 1986, 1988; Tsong, 1990, 1992). In order for a pump to capture energy another feature is essential: it must be able to interact effectively with a driving force, e.g., an electric field or an acoustic field (Tsong and Astumian, 1986, 1988).