癌症研究
复归
突变
DNA损伤
生物
化学
遗传学
聚ADP核糖聚合酶
DNA
基因
表型
聚合酶
作者
David A. Quigley,Joshi J. Alumkal,Alexander W. Wyatt,Vishal Kothari,Adam Foye,Paul Lloyd,Rahul Aggarwal,Won Bae Kim,Eric Lu,Jacob Schwartzman,Kevin Beja,Matti Annala,Rajdeep Das,Morgan E. Diolaiti,Colin C. Pritchard,George Thomas,Scott A. Tomlins,Karen E. Knudsen,Christopher J. Lord,Charles J. Ryan
出处
期刊:Cancer Discovery
[American Association for Cancer Research]
日期:2017-04-28
卷期号:7 (9): 999-1005
被引量:246
标识
DOI:10.1158/2159-8290.cd-17-0146
摘要
Approximately 20% of metastatic prostate cancers harbor mutations in genes required for DNA repair by homologous recombination repair (HRR) such as
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