Comprehensive high sour natural gas purification plant was discussed in the feed gas processing method of hydrogen sulfide gas absorption. The new solvent MDEA removal was selected for gas absorption solvent,on craft adopt two-stage absorption between alcohol amine desulfurization and cooling technology,the full absorption of hydrogen sulfide gas was fully implemented. In the process of hydrogen sulfide gas absorption,Puguang gas purification plant for the optimization of process parameters was optimized,finally,the general policy of energy saving and emission reduction were achieved.