Vascular targeting with phage peptide libraries

Pasqualini et al.has developed an in vivo selection system in which phage capable of selective homing to different tissues are recoved from a phage display peptide library following intravenous administration.The peptide that result from such a selection home to specific organs and tissues because they recognize molecular addresses,re-ceptors that are differentially expressed in viscular beds.Targeting delivery of chemotherapeutics,pro-apoptotic pep-tide and cytokines to tumors using these peptides improved therapeutic efficacy in animal models.Translation of this technology into clinical applications will form the basis for targeting therapeutic and imaging agents in the context of cancer and other diseases.