Objective To investigate the factors of major adverse cardiac events and symptomatic nursing methods with acute myocardial infarction after thrombolysis.Methods 60 patients with acute myocardial infarction and underwent successful thrombolytic therapy,Recorded the clinical data on detail and the major adverse cardiac events(MACE) during hospitalization and follow-up period of 60 days.Results The MACE rate was 8.3% in the hospital,and was 33.3% in followed up for 60 days.COX regression analysis showed that gender,left ventricular ejection fraction,history of diabetes were independent predictor of acute myocardial infarction with MACE.Conclusions The main factors of MACE after thrombolysis were gender,left ventricular ejection fraction,history of diabetes in the cute myocardial infarction after thrombolysis patient,the nurses should be familiar with the formation of MACE,and implement various nursing measures and carry out health guidance.