Study of the Expression of Nav1.7 in Dorsal Root Ganglion of Formalin-induced Paw Inflammatory Pain Model

Objective To investigate the Nav1.7 expression in the dorsal root ganglion of formalin-induced paw inflammatory pain model of the rat. Methods 24 Sprague-Dawley rats were divided into two groups: control rats(n=12) and formalin-induced paw inflammation rats(n =12). The controls were injected 0.1 mL NS, and formalin-induced rats were injected with 0.1ml saline formalin. L3-6 dorsal root ganglion were collected from rats. The expression of Nav1.7 was detected by real-time quantitative PCR and Western blot. Results Nav1.7 protein and mRNA expression in the dorsal root ganglion of formalin-induced paw inflammatory pain model were significant higher than the control group(P0.01﹚. Conclusion The Nav1.7 expression in the dorsal root ganglion of formalin-induced paw inflammatory pain model of the rat was significant higherthan before. It might be have some association with inflammatory pain.