假性剥脱综合征
蛋白质组
房水
青光眼
蛋白质组学
眼科
假性剥落
医学
化学
生物化学
基因
作者
Anna A. Kliuchnikova,Nadezhda I Samokhina,Irina Y. Ilina,Dmitry S. Karpov,Mikhail A. Pyatnitskiy,Ksenia G. Kuznetsova,I. Yu. Toropygin,S.A. Kochergin,И. Б. Алексеев,Victor G. Zgoda,Alexander I. Archakov,Sergei A. Moshkovskii
出处
期刊:Proteomics
[Wiley]
日期:2016-07-01
卷期号:16 (13): 1938-1946
被引量:51
标识
DOI:10.1002/pmic.201500423
摘要
Twenty‐nine human aqueous humor samples from patients with eye diseases such as cataract and glaucoma with and without pseudoexfoliation syndrome were characterized by LC–high resolution MS analysis. In total, 269 protein groups were identified with 1% false discovery rate including 32 groups that were not reported previously for this biological fluid. Since the samples were analyzed individually, but not pooled, 36 proteins were identified in all samples, comprising the constitutive proteome of the fluid. The most dominant molecular function of aqueous humor proteins as determined by GO analysis is endopeptidase inhibitor activity. Label‐free protein quantification showed no significant difference between glaucoma and cataract aqueous humor proteomes. At the same time, we found decrease in the level of apolipoprotein D as a marker of the pseudoexfoliation syndrome. The data are available from ProteomeXchange repository (PXD002623).
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