The relationship between serum level of IgG and proteinuria in children with nephrotic syndrome

Objective To investigate the relationship between serum IgG and proteinuria in children with nephrotic syndrome.Methods Biostatistics was used to study the relationship between the serum level of IgG and the quantitative changes of urine protein in 46 pediatric patients with simple primary nephrotic syndrome which had not been treated with steroid therapy.Results No linear regression,nor correlation was found between the serum IgG and the quantity of urine protein(P0.05).Conclusion Although lowered IgG level may be seen in some nephrotic children,the present investigation revealed no linear regression or correlation betweem serum IgG and proteinuria,suggesting that heavy proteinuria may not be the main cause of the lowering of serum IgG in children with nephrotic syndrome.