The Inhibition of the Histone Methyltransferase EZH2 by DZNEP or SiRNA Demonstrates Its Involvement in MGMT, TRA2A, RPS6KA2, and U2AF1 Gene Regulation in Prostate Cancer

OMICS: A Journal of Integrative BiologyVol. 24, No. 2 Letter to the EditorThe Inhibition of the Histone Methyltransferase EZH2 by DZNEP or SiRNA Demonstrates Its Involvement in MGMT, TRA2A, RPS6KA2, and U2AF1 Gene Regulation in Prostate CancerDriss El Ouardi, Mouhamed Idrissou, Anna Sanchez, Frédérique Penault-Llorca, Yves-Jean Bignon, Laurent Guy, and Dominique Bernard-GallonDriss El OuardiDepartment of Oncogenetics, Centre Jean Perrin, CBRV, Clermont-Ferrand, France.INSERM—U1240—Molecular Imaging and Theranostic Strategies (IMOST), Clermont-Ferrand, France.Search for more papers by this author, Mouhamed IdrissouDepartment of Oncogenetics, Centre Jean Perrin, CBRV, Clermont-Ferrand, France.INSERM—U1240—Molecular Imaging and Theranostic Strategies (IMOST), Clermont-Ferrand, France.Search for more papers by this author, Anna SanchezDepartment of Oncogenetics, Centre Jean Perrin, CBRV, Clermont-Ferrand, France.INSERM—U1240—Molecular Imaging and Theranostic Strategies (IMOST), Clermont-Ferrand, France.Search for more papers by this author, Frédérique Penault-LlorcaINSERM—U1240—Molecular Imaging and Theranostic Strategies (IMOST), Clermont-Ferrand, France.Department of Biopathology, Centre Jean Perrin, Clermont-Ferrand, France.Search for more papers by this author, Yves-Jean BignonDepartment of Oncogenetics, Centre Jean Perrin, CBRV, Clermont-Ferrand, France.INSERM—U1240—Molecular Imaging and Theranostic Strategies (IMOST), Clermont-Ferrand, France.Search for more papers by this author, Laurent GuyINSERM—U1240—Molecular Imaging and Theranostic Strategies (IMOST), Clermont-Ferrand, France.Department of Urology, Gabriel Montpied Hospital, Clermont-Ferrand, France.Search for more papers by this author, and Dominique Bernard-GallonAddress correspondence to, Dominique Bernard-Gallon, PhD, Department of Oncogenetics, Centre Jean Perrin, CBRV, INSERM U1240, 28 Place Henri Dunant, Clermont-Ferrand 63001, France E-mail Address: dominique.gallon-bernard@clermont.unicancer.frDepartment of Oncogenetics, Centre Jean Perrin, CBRV, Clermont-Ferrand, France.INSERM—U1240—Molecular Imaging and Theranostic Strategies (IMOST), Clermont-Ferrand, France.Search for more papers by this authorPublished Online:14 Feb 2020https://doi.org/10.1089/omi.2019.0162AboutSectionsView articleView Full TextPDF/EPUB Permissions & CitationsPermissionsDownload CitationsTrack CitationsAdd to favorites Back To Publication ShareShare onFacebookTwitterLinked InRedditEmail View articleFiguresReferencesRelatedDetailsCited byncRNAs mediated RPS6KA2 inhibits ovarian cancer proliferation via p38/MAPK signaling pathway19 January 2023 | Frontiers in Oncology, Vol. 13JMJD family proteins in cancer and inflammation1 September 2022 | Signal Transduction and Targeted Therapy, Vol. 7, No. 1Down regulation of U2AF1 promotes ARV7 splicing and prostate cancer progressionBiochemical and Biophysical Research Communications, Vol. 541The Functions of the Demethylase JMJD3 in Cancer19 January 2021 | International Journal of Molecular Sciences, Vol. 22, No. 2HNF1B, EZH2 and ECI2 in prostate carcinoma. Molecular, immunohistochemical and clinico-pathological study1 September 2020 | Scientific Reports, Vol. 10, No. 1 Volume 24Issue 2Feb 2020 InformationCopyright 2020, Mary Ann Liebert, Inc., publishersTo cite this article:Driss El Ouardi, Mouhamed Idrissou, Anna Sanchez, Frédérique Penault-Llorca, Yves-Jean Bignon, Laurent Guy, and Dominique Bernard-Gallon.The Inhibition of the Histone Methyltransferase EZH2 by DZNEP or SiRNA Demonstrates Its Involvement in MGMT, TRA2A, RPS6KA2, and U2AF1 Gene Regulation in Prostate Cancer.OMICS: A Journal of Integrative Biology.Feb 2020.116-118.http://doi.org/10.1089/omi.2019.0162Published in Volume: 24 Issue 2: February 14, 2020Online Ahead of Print:December 31, 2019PDF download