Research progress on the relationship between transforming growth factor-β1 and hepatic fibrosis

Transforming growth factor-β1 (TGF-β1) is the strongest hepatic fibrosis promoter. It can inhibit the proliferation of hepatic cells, endothelial cells and epithelial cells, promote the synthesis of extracellular matrix (ECM), induce the apoptosis of hepatic cells, and promote the activation of hepatic stellate cells (HSC). Knowing the mechanism how TGF-β1 causes hepatic fibrosis has significance in the diagnosis and treatment of hepatic fibrosis. Key words: Transforming growth factor-β1; Hepatic fibrosis; Extracellular matrix; Hepatic stellate cells