光热治疗
光敏剂
纳米载体
体内
材料科学
光动力疗法
分子成像
纳米技术
纳米医学
癌症研究
医学
药物输送
化学
纳米颗粒
生物
生物技术
有机化学
作者
Xuanbo Zhang,Bingjun Sun,Shiyi Zuo,Qin Chen,Yanlin Gao,Hanqing Zhao,Mengchi Sun,Pengyu Chen,Han Ye,Wenjuan Zhang,Kaiyuan Wang,Ruoshi Zhang,Qiming Kan,Haotian Zhang,He Zhang,Cong Luo,Jin Sun
标识
DOI:10.1021/acsami.8b10421
摘要
Imaging-guided diagnosis and phototherapy has been emerging as promising theragnostic strategies for detection and treatment of cancer. 1,1′-Dioctadecyl-3,3,3′,3′-tetramethylindotricarbocyanine iodide (DiR) has been widely investigated for in vivo imaging and photothermal therapy (PTT). However, the tumor-homing ability and PTT efficiency of DiR is greatly limited by its extremely low water solubility and nonspecific distribution in off-target tissues. Herein, a facile nanoassembly of pure DiR is reported as a theragnostic nanocarrier platform for imaging-guided antitumor phototherapy. Self-assembly of DiR has almost no effect on its in vitro photothermal efficacy when compared with DiR solution. Interestingly, the PEGylated nanoassemblies of DiR showed distinct advantages over DiR solution and non-PEGylated nanoassemblies in terms of systemic circulation and tumor-homing capability in vivo. As a result, PEGylated DiR nanoassemblies demonstrate potent photothermal tumor therapy in BALB/c mice bearing 4T1 xenograft tumors. Such a pure photosensitizer-based nanoassembly holds great potential as a versatile platform for efficient imaging-guided cancer therapy.
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