肠易激综合征
肠-脑轴
肠神经系统
肠道菌群
免疫系统
神经科学
神经递质
多巴胺
医学
胃肠道
胃肠功能
生物
生物信息学
免疫学
内科学
中枢神经系统
作者
Minjia Chen,Guangcong Ruan,Lu Chen,Senhong Ying,Guanhu Li,Fenghua Xu,Zhifeng Xiao,Yuting Tian,Linling Lv,Ping Yi,Yi Cheng,Yanling Wei
标识
DOI:10.3389/fendo.2022.817100
摘要
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder of unknown etiology. IBS is caused by a disruption in the gut-brain axis. Given the importance of the gut microbiota in maintaining local and systemic homeostasis of immunity, endocrine, and other physiological processes, the microbiota-gut-brain axis has been proposed as a key regulator in IBS. Neurotransmitters have been shown to affect blood flow regulation, intestinal motility, nutrient absorption, the gastrointestinal immune system, and the microbiota in recent studies. It has the potential role to play a function in the pathophysiology of the gastrointestinal and neurological systems. Transmitters and their receptors, including 5-hydroxytryptamine, dopamine, γ-aminobutyric acid, and histamine, play an important role in IBS, especially in visceral sensitivity and gastrointestinal motility. Studies in this field have shed light on revealing the mechanism by which neurotransmitters act in the pathogenesis of IBS and discovering new therapeutic strategies based on traditional pharmacological approaches that target the nervous system or novel therapies that target the microbiota.
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