立体化学
嘧啶
对映选择合成
链霉菌
化学
链霉菌科
化学合成
放线菌
生物
生物化学
细菌
体外
催化作用
遗传学
作者
Niraj Aryal,Junhong Chen,Keshab Bhattarai,Oliver Hennrich,Ira Handayani,M. Krämer,Jan Straetener,Tatjana Wommer,Anne Berscheid,Silke Peter,Norbert Reiling,Heike Brötz‐Oesterhelt,Christian Geibel,Michael Lämmerhofer,Yvonne Mast,Harald Gross
标识
DOI:10.1021/acs.jnatprod.1c01051
摘要
A chemical reinvestigation of the Indonesian strain Streptomyces sp. SHP 22-7 led to the isolation of three new pyrimidine nucleosides, along with six known analogues and zincphyrin. The structures of the new compounds (6, 7, 10) were elucidated by employing spectroscopic techniques (NMR, MS, CD, and IR) as well as enantioselective analyses of methyl branched side chain configurations. Application of the precursor-directed feeding approach led to the production and partial isolation of nine further pyrimidine analogues. The new compounds 6, 7, and 11 and three of the known compounds (2-4) were found to possess antimycobacterial and cytotoxic properties.
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