Neuropsychological Functioning in Primary Dystonia: Updated and Expanded Multidomain Meta‐Analysis

Abstract Background Primary dystonia is conventionally considered as a motor disorder, though an emerging literature reports associated cognitive dysfunction. Objectives Here, we conducted meta‐analyses on studies comparing clinical measures of cognition in persons with primary dystonia and healthy controls (HCs). Methods We searched PubMed, Embase, Cochrane Library, Scopus, and PsycINFO (January 2000–October 2020). Analyses were modeled under random effects. We used Hedge's g as a bias‐corrected estimate of effect size, where negative values indicate lower performance in dystonia versus controls. Between‐study heterogeneity and bias were primarily assessed with Cochran's Q , I 2 , and Egger's regression. Results From 866 initial results, 20 studies met criteria for analysis (dystonia n = 739, controls n = 643; 254 effect sizes extracted). Meta‐analysis showed a significant combined effect size of primary dystonia across all studies ( g = −0.56, P < 0.001), with low heterogeneity ( Q = 25.26, P = 0.15, I 2 = 24.78). Within‐domain effects of primary dystonia were motor speed = −0.84, nonmotor speed = −0.83, global cognition = −0.65, language = −0.54, executive functioning = −0.53, learning/memory = −0.46, visuospatial/construction = −0.44, and simple/complex attention = −0.37 ( P ‐values <0.01). High heterogeneity was observed in the motor/nonmotor speed and learning/memory domains. There was no evidence of publication bias. Moderator analyses were mostly negative but possibly underpowered. Blepharospasm samples showed worse performance than other focal/cervical dystonias. Those with inherited (ie, genetic) disease etiology demonstrated worse performance than acquired. Conclusions Dystonia patients consistently demonstrated lower performances on neuropsychological tests versus HCs. Effect sizes were generally moderate in strength, clustering around −0.50 SD units. Within the speed domain, results suggested cognitive slowing beyond effects from motor symptoms. Overall, findings indicate dystonia patients experience multidomain cognitive difficulties, as detected by neuropsychological tests. © 2022 International Parkinson and Movement Disorder Society