作者
Olga Meltem Akay,Murat Özbalak,Mustafa Pehlıvan,Birol Yıldız,Ant Uzay,Tuğçe Nur Yiğenoğlu,Tuğrul Elverdi,Leylagül Kaynar,Orhan Ayyıldız,İpek Yönal Hindilerden,Hasan Sami Göksoy,Şebnem İzmir Güner,Ahmet Kürşad Güneş,Mehmet Sönmez,Meltem Kurt Yüksel,Sinem Civriz Bozdağ,Zübeyde Nur Özkurt,Tayfur Toptaş,Mehmet Hilmi Doğu,Ozan Salim,Güray Saydam,İrfan Yavaşoğlu,Meltem Aylı,Gülsüm Özet,Murat Albayrak,Elif Birtaş Ateşoğlu,Selami Koçak Toprak,Rahşan Yıldırım,Özgür Mehtap,Sevgi Kalayoğlu Beşışık,Meliha Nalçacı,Fevzi Altuntaş,Burhan Ferhanoğlu
摘要
Abstract The AETHERA trial reported an increased progression‐free survival (PFS) when brentuximab vedotin (BV) was used as maintenance therapy in high‐risk Hodgkin lymphoma (HL) after autologous stem cell transplantation (ASCT). Thus, we aimed to determine the impact and safety of BV as maintenance after ASCT in real‐world patients. Seventy‐five patients with relapsed/refractory HL started on BV consolidation therapy after ASCT due to high risk of relapse, between January 2016 and July 2019, from 25 institutions, were included in the study. The median follow‐up time was 26 months. The most common high‐risk features were primary refractory or relapsed disease <12 months ( n = 61), lack of complete response (CR) to the last salvage regimen ( n = 51), and having had at least two salvage regimens ( n = 29). At the time of analysis, 42 patients completed consolidation courses, and BV was discontinued in 33 patients. Fifty patients had an ongoing response (CR in 41, PR in 6, and SD in 3 patients), 25 had progressed. Ten died in the follow‐up, eight with progressive disease and two due to infection while in CR. The 2‐year PFS and OS rates were 67.75% (95% confidence interval [CI]: 0.55–0.77) and 87.61% (95% CI: 0.76–0.94), respectively. Seventeen patients (23%) received BV in the pre‐ASCT treatment lines, and there was no survival difference between the BV‐naïve and BV‐exposed groups. The most common adverse events were neutropenia (27%) and peripheral neuropathy (21%). Sixteen patients (21.3%) experienced grade 3 or 4 toxicity. BV was discontinued due to adverse event in 12 patients. Consolidation with BV after ASCT can achieve a 2‐year PFS of 67.75% (95% CI: 0.55–0.75) with an acceptable toxicity profile.