The injury endotheliocytes of hepatic sinusoid after liver transplantation

Objective To inquiry pathological changes of endotheliocytes of hepatic sinusoid while reperfusion and rejection occurred after liver transplantation.Methods We stained liver specimen sampled termly with monoclonal antibodies to endotheliocytes of hepatic sinusoid in rat.Results ICAM 1 was stained markedly in hepatic sinusoid at 4th day,but we didn't find laminine and Ⅷ associated antigen during experiment.Clearly ICAM 1 stained was found in highly rejected group(ACI LEW)from the first day after transplantation.In the medium group (BN LEW),we detected that ICAM 1 was stained at 1st day after transplantation,and Ⅷ associated antigen was found in hepatic sinusoid.Conclusion The liver injury resulted from chronic rejection not only destroy hepatic artery but also injure hepatic sinusoid.