Objective: To observe the clinic-effects of acne vulgaris treated by oral administration of Chinese medicine combined with isotretinoin erythromycin gel.Method: A total of 100 cases was randomly divided into two group.Patients of the therapeutic group(n=56) were treated with Chinese medicine orally administration combined with isotretinoin erythromycin gel.Patients of the control group(n=44) were treated with oral administration of Chinese medicine.The treatment duration of 2 groups was 30 days.Result: After the treatment,the therapeutic effect of the therapeutic group was superior to that of the control group(P0.05).Conclusion: The therapeutic effect of oral administration of Chinese medicine combined with isotretinoin erythromycin gel was superior to simple therapy of oral administration of Chinese medicine.