Clinical efficacy of intratumoral injection with highly agglutinative staphylococci plus radiotherapy in the patients with recurrent nasopharyngeal carcinoma

Objective:To evaluate the effect of highly agglutinative staphylococci(HAS)intratumoral injection plus radiotherapy in the treatment of recurrent nasopharyngeal carcinoma(NPC).Methods:A total of 41 patients with recurrent nasopharyngeal carcinoma were treated with HAS intratumoral injection and intramuscular plus conventional radiotherapy.Results:The nasopharyngeal control rates were CR 43.9%,PR 41.5%,NC4.6% and PD 0% respectively.The cervical lymph nodes control rates were CR 41.5%,PR 46.3%,NC12.2% and PD 0% respectively.The 1-,2-,3-year survival rate were 80.48%(33/41),62.50%(25/40) and 47.50%(19/40) respectively.The distant metastases rate was 7.3%(3/41)for 3 years.Conclusion:HAS intratumoral injection and intramuscular plus radiotherapy are beneficial to the recurrent nasopharyngeal carcinoma and the cervical lymph nodes control.It may decrease the distant metastases and improve the quality of life.Intratumoral injection with HAS is a simple,safe,and effective alternative for the treatment of recurrent nasopharyngeal carcinoma.