Research on Free-Radical Degradation in Vitro of Hydroxypropyl Methyl Cellulose

Hydroxypropyl methyl cellulose(HPMC),a kind of cosmetic-filling material,was degraded in vitro by Fenton-AH-H2O2 system imitating the reactive oxygen species(ROS) in vivo.By detecting the variation of molecular weight and dynamic viscosity of HPMC,it was demonstrated that,in the degradation process,the decrease of molecular weight of E3-HPMC and E50-HPMC was 90%,and the decrease of dynamic viscosity of E4M-HPMC and E10M-HPMC was 75% and 40%,respectively.It was illustrated that HPMC was degraded obviously by ROS.