Objective To observe the wrinkle reducing effect of Evolution when used together with Botulinum Toxin.Methods Evolution was injected into the wrinkle site,and then the Botulinum Toxin was injected into the mark point near the wrinkle.Results A 1~2 year followed-up of sixty-nine patients showed satisfactory results.The satisfactory rate and effective rate were 89.6% and 99%,respectively.Conclusion Combined use of Evolution and Botulinum Toxin for wrinkle reduction has a promising future in cosmetic surgery.