Candesartan time therapeutic effects on non-dipper hypertension

Objectives To observe the candesartan time therapeutic effects on blood pressure levels and blood pressure circadian rhythm in patients with non dipper hypertension. Methods We selected 106 cases with non dipper hypertension(grade 1 hypertension) who needed medication by 24 h ambulatory blood pressure monitoring. The patients were randomly divided into A group(medication at 7:00 in the morning) and B group(19:00 medication). Candesartan(4 mg) was used in the two groups. Blood pressure circadian rhythm of the two groups were measured by 24 h ambulatory blood pressure monitoring before and after 8 weeks treatment. Results Compared with those of before treatment, 24 h systolic blood pressure(SBP), 24 h diastolic blood pressure(DBP), dSBP, dDBP, nSBP, nDBP were significantly lower after 8 weeks treatment in both the two groups, the differences were statistically significant(P0.05).Compared with those of before treatment, 24 h DBP, dSBP, dDBP, nDBP had no statistical significance in the two groups after treatment(P 0.05). 24 h SBP and nSBP in group B were significantly improved than those in group A(P 0.05).Conclusions Candesartan taken in the morning or at night can effectively reduce the blood pressure levels in patients with non dipper hypertension and improve blood pressure circadian rhythm, but taken in nighttime had better effect on systolic blood pressure control and blood pressure circadian rhythm.