An experimental study of ~(99)Tc~m-HL91 in detection of myocardial viability

Objective To investigate whether 99 Tc m 4,9 diaza 3,3,10,10 tetramethyldodecan 2,11 dione dioxime (HL91) can be used to distinguish ischemic myocardium segments from infarction segments. Methods Twenty five acute myocardial infarction patients (≤6 weeks) and 5 old myocardial infarction patients (6 weeks) were included in the study. All the study patients underwent 99 Tc m HL91 and 99 Tc m methoxyisobutylisonitrile (MIBI) imaging intervented and unintervented with nitroglycerin, and the myocardium segments were divided into three groups according to 99 Tc m MIBI imaging results: normal, ischemic, and infarction myocardium segments. The difference of the radial counts of 99 Tc m HL91 in three groups were analyzed after the imaging with 99 Tc m HL91. Results ①In acute myocardial infarction patients, the accumulation rates of 99 Tc m HL91 was 95%in normal segment group, 157%in ischemic group, 93%in infarction group. The accumulation rates of 99 Tc m HL91 in the ischemic group was higher than that in the normal group and infarction group. ②In old myocardial infarction patients, the accumulation rates of 99 Tc m HL91 were of no difference among the normal, ischemic, and infarction groups. Conclusion 99 Tc m HL91 is a potential marker for detecting the ischemic myocardial tissue.