Assessment and Comparison of Nonlinear Measures in Resting-State Magnetoencephalograms in Alzheimer’s Disease and Mild Cognitive Impairment

认知障碍 听力学 阿尔茨海默病 关联维数 相关性 静息状态功能磁共振成像 近似熵 认知 内科学 心理学 心脏病学 数学 医学 分形维数 疾病 分形 模式识别(心理学) 神经科学 认知心理学 数学分析 几何学
作者
Hamed Azami,Elham Daftarifard,Anne Humeau-Heurtier,Alberto Fernández,Daniel Abásolo,Tarek K. Rajji
出处
期刊:Journal of Alzheimer's Disease [IOS Press]
卷期号:96 (3): 1151-1162
标识
DOI:10.3233/jad-230544
摘要

Background:Nonlinear dynamical measures, such as fractal dimension (FD), entropy, and Lempel-Ziv complexity (LZC), have been extensively investigated individually for detecting information content in magnetoencephalograms (MEGs) from patients with Alzheimer’s disease (AD). Objective:To compare syst ematically the performance of twenty conventional and recently introduced nonlinear dynamical measures in studying AD versus mild cognitive impairment (MCI) and healthy control (HC) subjects using MEG. Methods:We compared twenty nonlinear measures to distinguish MEG recordings from 36 AD (mean age = 74.06±6.95 years), 18 MCI (mean age = 74.89±5.57 years), and 26 HC subjects (mean age = 71.77±6.38 years) in different brain regions and also evaluated the effect of the length of MEG epochs on their performance. We also studied the correlation between these measures and cognitive performance based on the Mini-Mental State Examination (MMSE). Results:The results obtained by LZC, zero-crossing rate (ZCR), FD, and dispersion entropy (DispEn) measures showed significant differences among the three groups. There was no significant difference between HC and MCI. The highest Hedge’s g effect sizes for HC versus AD and MCI versus AD were respectively obtained by Higuchi’s FD (HFD) and fuzzy DispEn (FuzDispEn) in the whole brain and was most prominent in left lateral. The results obtained by HFD and FuzDispEn had a significant correlation with the MMSE scores. DispEn-based techniques, LZC, and ZCR, compared with HFD, were less sensitive to epoch length in distinguishing HC form AD. Conclusions:FuzDispEn was the most consistent technique to distinguish MEG dynamical patterns in AD compared with HC and MCI.
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