Cucurbitacin‐E‐Glucoside Augments Tamoxifen's Anticancer Efficacy by Targeting PPARγ and NF‐kB: In Vivo and In Silico Studies

Our findings show that CEG therapy activates apoptotic PPARα and PPARγ genes and suppresses anti-apoptotic Bcl-2 and HIF-1Α genes, while reducing the oxidative stress and inflammation in EAC cells through a mechanism involving inhibition of NF-kβ. Finally, CEG creates a safe and synergistic environment that amplifies the therapeutic benefits of tamoxifen.