Cardiovascular Implications of Gynecological Disorders: Bridging the Gap Between Gynecology and Cardiology

医学 子宫内膜异位症 多囊卵巢 疾病 心肌梗塞 子宫内膜癌 代谢综合征 妇科 重症监护医学 癌症 内科学 生物信息学 肥胖 胰岛素抵抗 生物
作者
Ashish Kumar Tripathi,Sanjana Arsha,Anish Thapa,Sangharsha Thapa,Swati Chand,William H. Frishman,Wilbert Aronow
出处
期刊:Cardiology in Review [Lippincott Williams & Wilkins]
标识
DOI:10.1097/crd.0000000000000759
摘要

Gynecological disorders such as endometriosis, polycystic ovary syndrome, and gynecological cancers are increasingly recognized as potential risk factors for cardiovascular disease (CVD). Endometriosis, a chronic inflammatory condition, exhibits shared pathogenic mechanisms with CVD, including endothelial dysfunction and an atherogenic lipid profile. Emerging evidence suggests a link between endometriosis and an elevated risk of cardiovascular events such as myocardial infarction, ischemic heart disease, and hypertension. Polycystic ovary syndrome, characterized by hormonal imbalances and metabolic derangements, is associated with an increased risk of hypertension, myocardial infarction, and structural cardiac abnormalities, even after controlling for obesity. Gynecological cancers, such as ovarian, endometrial, and cervical cancers, are also associated with an increased burden of cardiovascular comorbidities and mortality. Cancer treatments, including chemotherapy and radiation therapy, can further contribute to cardiovascular toxicity. Understanding the interplay between gynecological disorders and CVD is crucial for identifying high-risk individuals, implementing preventive strategies, and providing comprehensive care. A multidisciplinary approach involving gynecologists, cardiologists, and other specialists is essential for optimizing the management of these complex conditions and improving overall patient outcomes.
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