子宫内膜异位症
Wnt信号通路
疾病
生物信息学
小RNA
血管生成
连环素
医学
癌症研究
不育
盆腔疼痛
生物
信号转导
病理
细胞生物学
遗传学
基因
放射科
怀孕
作者
Zujiang Yu,Xiaoyang Sun,Zhongkang Li,Xiaohui Han,Wenjun Wang,Penglin Xu,Yangyang Liu,Yuna Xue,Zhe Wang,Shuling Xu,Xueying Wang,Gailing Li,Yanpeng Tian,Qian Zhao
标识
DOI:10.1016/j.biopha.2024.116182
摘要
Endometriosis is a disease characterized by the ectopic growth of endometrial tissue (glands and stroma) outside the confines of the uterus and often involves vital organs such as the intestines and urinary system. Endometriosis is considered a refractory disease owing to its enigmatic etiology, propensity for recurrence following conservative or surgical interventions, and the absence of radical treatment and long-term management. In recent years, the incidence of endometriosis has gradually increased, rendering it a pressing concern among women of childbearing age. A more profound understanding of its pathogenesis can significantly improve prognosis. Recent research endeavors have spotlighted the molecular mechanisms by which microRNAs (miRNAs) regulate the occurrence and progression of endometriosis. Many miRNAs have been reported to be aberrantly expressed in the affected tissues of both patients and animal models. These miRNAs actively participate in the regulation of inflammatory reactions, cellular proliferation, angiogenesis, and tissue remodeling. Their capacity to modulate crucial signaling pathways, such as the Wnt/β-catenin signaling pathway, reinforces their potential utility as diagnostic markers or therapeutic agents for endometriosis. In this review, we provide the latest insights into the role of miRNAs that interact with the Wnt/β-catenin pathway to regulate the biological behaviors of endometriosis cells and disease-related symptoms, such as pain and infertility. We hope that this review will provide novel insights and promising targets for innovative therapies addressing endometriosis.
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