头颈部鳞状细胞癌
头颈部癌
肿瘤微环境
体内
间质细胞
细胞培养
癌症研究
医学
三维细胞培养
类有机物
体外
癌症
生物
病理
肿瘤科
内科学
神经科学
生物化学
遗传学
生物技术
作者
Anuraag S. Parikh,Victoria X. Yu,Samuel Flashner,Ogoegbunam Okolo,Chao Lü,Brian S. Henick,Fatemeh Momen‐Heravi,Sidharth V. Puram,Theodoros N. Teknos,Quintin Pan,Hiroshi Nakagawa
出处
期刊:Oral Oncology
[Elsevier]
日期:2023-03-01
卷期号:138: 106330-106330
被引量:2
标识
DOI:10.1016/j.oraloncology.2023.106330
摘要
Head and neck squamous cell carcinoma (HNSCC) outcomes remain stagnant, in part due to a poor understanding of HNSCC biology. The importance of tumor heterogeneity as an independent predictor of outcomes and treatment failure in HNSCC has recently come to light. With this understanding, 3D culture systems, including patient derived organoids (PDO) and organotypic culture (OTC), that capture this heterogeneity may allow for modeling and manipulation of critical subpopulations, such as p-EMT, as well as interactions between cancer cells and immune and stromal cells in the microenvironment. Here, we review work that has been done using PDO and OTC models of HNSCC, which demonstrates that these 3D culture models capture in vivo tumor heterogeneity and can be used to model tumor biology and treatment response in a way that faithfully recapitulates in vivo characteristics. As such, in vitro 3D culture models represent an important bridge between 2D monolayer culture and in vivo models such as patient derived xenografts.
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