炎症体
萧条(经济学)
炎症
医学
细胞因子
临床试验
神经科学
生物信息学
免疫学
心理学
生物
内科学
宏观经济学
经济
作者
Salona Roy,Md. Arif Ansari,Khushboo Choudhary,Sanjiv Singh
标识
DOI:10.1016/j.intimp.2023.109916
摘要
The present article provides a detailed concept of the role of NLRP3 inflammasome in the pathophysiology of depression-like chronic diseases where inflammation and release of various cytokines plays a pivotal role in exaggerating the condition. The various pathways involved in NLRP3 activation are the main target of NLRP3 inhibitors for the therapeutic management of depression as per the recent clinical and research studies conducted so far. Further various drug inhibitors for NLRP3 available in preclinical and clinical trials have been discussed in detail. Hence, blockage of the action of NLRP3 inflammasome is crucial to anticipate the inflammatory cytokine release from the mediators that contributes to cause depression.
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