Monocyte‐Derived Macrophages Aggravate Cardiac Dysfunction After Ischemic Stroke in Mice

医学 CCR2型 心功能曲线 交感神经切除术 心脏病学 冲程(发动机) 促炎细胞因子 单核细胞 内科学 渗透(HVAC) 缺血 炎症 趋化因子 趋化因子受体 心力衰竭 工程类 物理 热力学 机械工程
作者
Hong‐Bin Lin,Pu Hong,M. Yin,Zhijun Yao,Jin‐Yu Zhang,Yaodong Jiang,Xuan‐Xuan Huang,Shiyuan Xu,Fengxian Li,Hong‐Fei Zhang
出处
期刊:Journal of the American Heart Association [Ovid Technologies (Wolters Kluwer)]
标识
DOI:10.1161/jaha.123.034731
摘要

Background Cardiac damage induced by ischemic stroke, such as arrhythmia, cardiac dysfunction, and even cardiac arrest, is referred to as cerebral‐cardiac syndrome (CCS). Cardiac macrophages are reported to be closely associated with stroke‐induced cardiac damage. However, the role of macrophage subsets in CCS is still unclear due to their heterogeneity. Sympathetic nerves play a significant role in regulating macrophages in cardiovascular disease. However, the role of macrophage subsets and sympathetic nerves in CCS is still unclear. Methods and Results In this study, a middle cerebral artery occlusion mouse model was used to simulate ischemic stroke. ECG and echocardiography were used to assess cardiac function. We used Cx3cr1 GFP Ccr2 RFP mice and NLRP3 ‐deficient mice in combination with Smart‐seq2 RNA sequencing to confirm the role of macrophage subsets in CCS. We demonstrated that ischemic stroke‐induced cardiac damage is characterized by severe cardiac dysfunction and robust infiltration of monocyte‐derived macrophages into the heart. Subsequently, we identified that cardiac monocyte‐derived macrophages displayed a proinflammatory profile. We also observed that cardiac dysfunction was rescued in ischemic stroke mice by blocking macrophage infiltration using a CCR2 antagonist and NLRP3 ‐deficient mice. In addition, a cardiac sympathetic nerve retrograde tracer and a sympathectomy method were used to explore the relationship between sympathetic nerves and cardiac macrophages. We found that cardiac sympathetic nerves are significantly activated after ischemic stroke, which contributes to the infiltration of monocyte‐derived macrophages and subsequent cardiac dysfunction. Conclusions Our findings suggest a potential pathogenesis of CCS involving the cardiac sympathetic nerve–monocyte‐derived macrophage axis.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
咕咕发布了新的文献求助10
1秒前
4秒前
别处夕阳发布了新的文献求助10
5秒前
7秒前
负责冰烟发布了新的文献求助10
8秒前
8秒前
上官若男应助文献蚂蚁采纳,获得10
8秒前
十二完成签到 ,获得积分10
9秒前
12秒前
13秒前
情怀应助火星上的雨莲采纳,获得10
13秒前
cyh413134发布了新的文献求助10
13秒前
13秒前
那英东完成签到 ,获得积分10
14秒前
16秒前
16秒前
萨特发布了新的文献求助10
16秒前
嗯嗯发布了新的文献求助10
20秒前
tzy发布了新的文献求助10
21秒前
21秒前
24秒前
万能图书馆应助冰山未闯采纳,获得10
26秒前
29秒前
32秒前
别处夕阳完成签到 ,获得积分10
35秒前
KK早睡晚起完成签到,获得积分10
36秒前
我是娃娃完成签到,获得积分20
37秒前
zcx完成签到,获得积分10
38秒前
42秒前
42秒前
42秒前
43秒前
terence发布了新的文献求助10
46秒前
文献蚂蚁发布了新的文献求助10
47秒前
大气新烟完成签到 ,获得积分10
47秒前
拼命十三娘完成签到,获得积分10
48秒前
Jasper应助HouShipeng采纳,获得10
50秒前
在水一方应助科研通管家采纳,获得10
52秒前
Hello应助科研通管家采纳,获得10
52秒前
田様应助科研通管家采纳,获得10
52秒前
高分求助中
Sustainable Land Management: Strategies to Cope with the Marginalisation of Agriculture 1000
Corrosion and Oxygen Control 600
Python Programming for Linguistics and Digital Humanities: Applications for Text-Focused Fields 500
Love and Friendship in the Western Tradition: From Plato to Postmodernity 500
Heterocyclic Stilbene and Bibenzyl Derivatives in Liverworts: Distribution, Structures, Total Synthesis and Biological Activity 500
重庆市新能源汽车产业大数据招商指南(两链两图两池两库两平台两清单两报告) 400
Division and square root. Digit-recurrence algorithms and implementations 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 有机化学 工程类 生物化学 纳米技术 物理 内科学 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 电极 光电子学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 2548921
求助须知:如何正确求助?哪些是违规求助? 2176710
关于积分的说明 5605969
捐赠科研通 1897471
什么是DOI,文献DOI怎么找? 947024
版权声明 565447
科研通“疑难数据库(出版商)”最低求助积分说明 503985