Effects of Non‐Surgical Treatment on Hematological Indices in Stage III/IV Grade C Periodontitis

ABSTRACT Objective To investigate the short‐term effects of non‐surgical periodontal treatment (NSPT) on clinical and hematological indices in stage III/IV grade C periodontitis patients. Methods A total of 121 systemically healthy patients with generalized stage III/IV, grade C periodontitis were enrolled. Clinical indices (plaque index, probing depth, bleeding index, attachment loss) and hematological biomarkers [white blood cell count (WBC), mean platelet volume (MPV), neutrophil count (NEUT), neutrophil percentage (NEUT%), lymphocyte percentage (LYM%)] were measured before and 6–8 weeks after NSPT. Patients were divided into younger (≤ 35 years) and elder (> 35 years) groups, further stratified by systemic antibiotics usage. Analyses were performed using chi‐squared tests, paired t ‐tests, and Pearson's correlation. Results NSPT resulted in clinical indices improvement, as well as a reduction in WBC, NEUT, NEUT%, and an increase in MPV and LYM% in both groups. SRP‐with‐antibiotics subgroups showed more significant changes. SRP‐without‐antibiotics subgroups showed six significant correlations in both groups ( p < 0.05); SRP‐with‐antibiotics subgroups showed 11 correlations in the younger and five in the elder group ( p < 0.05). Conclusions NSPT improved clinical and hematological outcomes in stage III/IV grade C periodontitis patients over 6–8 weeks. Younger patients exhibited more significant changes than elder patients, especially in the SRP‐without‐antibiotics subgroup.