计算机科学
期限(时间)
毫秒
神经科学
生物
物理
天文
量子力学
作者
Nicholas A. Steinmetz,Çağatay Aydın,Anna Lebedeva,Michael Okun,Marius Pachitariu,Marius Bauža,Maxime Beau,Jai Bhagat,Claudia Böhm,Martijn Broux,Susu Chen,Jennifer Colonell,Richard J. Gardner,Bill Karsh,Fabian Kloosterman,Dimitar Kostadinov,Carolina Mora López,John O’Callaghan,Junchol Park,Jan Putzeys
出处
期刊:Science
[American Association for the Advancement of Science]
日期:2021-04-15
卷期号:372 (6539)
被引量:855
标识
DOI:10.1126/science.abf4588
摘要
Measuring the dynamics of neural processing across time scales requires following the spiking of thousands of individual neurons over milliseconds and months. To address this need, we introduce the Neuropixels 2.0 probe together with newly designed analysis algorithms. The probe has more than 5000 sites and is miniaturized to facilitate chronic implants in small mammals and recording during unrestrained behavior. High-quality recordings over long time scales were reliably obtained in mice and rats in six laboratories. Improved site density and arrangement combined with newly created data processing methods enable automatic post hoc correction for brain movements, allowing recording from the same neurons for more than 2 months. These probes and algorithms enable stable recordings from thousands of sites during free behavior, even in small animals such as mice.
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