创伤性脑损伤
恐惧条件反射
心理学
啮齿动物模型
提示语
相关性(法律)
神经科学
转化研究
创伤后应激
临床心理学
精神科
医学
认知心理学
扁桃形结构
内科学
病理
法学
政治学
作者
Claire Kostelnik,Irwin Lucki,Kwang Ho Choi,Caroline A. Browne
标识
DOI:10.1016/j.neubiorev.2021.04.037
摘要
Mild traumatic brain injury (mTBI) increases the risk of posttraumatic stress disorder (PTSD) in military populations. Utilizing translationally relevant animal models is imperative for establishing a platform to delineate neurobehavioral deficits common to clinical PTSD that emerge in the months to years following mTBI. Such platforms are required to facilitate preclinical development of novel therapeutics. First, this mini review provides an overview of the incidence of PTSD following mTBI in military service members. Secondly, the translational relevance of fear conditioning paradigms used in conjunction with mTBI in preclinical studies is evaluated. Next, this review addresses an important gap in the current preclinical literature; while incubation of fear has been studied in other areas of research, there are relatively few studies pertaining to the enhancement of cued and contextual fear memory over time following mTBI. Incubation of fear paradigms in conjunction with mTBI are proposed as a novel behavioral approach to advance this critical area of research. Lastly, this review discusses potential neurobiological substrates implicated in altered fear memory post mTBI.
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