电化学
阳极
催化作用
氘
化学选择性
化学
氧化物
化学计量学
阴极
无机化学
金属
化学反应
石墨
电极
有机化学
物理化学
物理
量子力学
作者
Xu Liu,Ruo-Yu Liu,Jiaxing Qiu,Xu Cheng,Guigen Li
标识
DOI:10.1002/anie.202005765
摘要
We report a method for the electrochemical deuteration of α,β-unsaturated carbonyl compounds under catalyst- and external-reductant-free conditions, with deuteration rates as high as 99 % and yields up to 91 % in 2 h. The use of graphite felt for both the cathode and the anode was key to ensuring chemoselectivity and high deuterium incorporation under neutral conditions without the need for an external reductant. This method has a number of advantages over previously reported deuteration reactions that use stoichiometric metallic reductants. Mechanistic experiments showed that O2 evolution at the anode not only eliminates the need for an external reductant but also regulates the pH of the reaction mixture, keeping it approximately neutral.
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