解码方法
编码器
计算机科学
级联
DNA
DNA运算
化学
组合化学
算法
生物化学
色谱法
操作系统
作者
Lili Zhang,Linlin Wang,Xi Yuan,Minjuan Zhong,Hong Chen,Dailiang Zhang,Xiaoyan Han,Sitao Xie,Lei He,Yazhou Li,Fengming Chen,Yanlan Liu,Weihong Tan
标识
DOI:10.1002/anie.202014088
摘要
DNA-based molecular communications (DMC) are critical for regulating biological networks to maintain stable organismic functions. However, the complicated, time-consuming information transmission process involved in genome-coded DMC and the limited, vulnerable decoding activity generally lead to communication impairment or failure, in response to external stimuli. Herein, we present a conceptually innovative DMC strategy mediated by the DNA framework-based artificial DNA encoder. With the free-radical cascade as a proof-of-concept study, the artificial DNA encoder shows active sensing and real-time actuation, in situ and broad free radical-decoding efficacy, as well as robust resistance to environmental noise. It can also block undesirable short-to-medium-range communications between free radicals and inflammatory networks, leading to a synergistic anti-obesity effect. The artificial DNA encoder-based DMC may be generalized to other communication systems for a variety of applications.
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